Journal Article

FZJ-2015-07879

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Changes in nutritional status after deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s disease — Results of a phase I study

Noreik, M. (Corresponding author) ; Kuhn, J. ; Hardenacke, K. ; Lenartz, D. ; Bauer, A.FZJ* ; Bührle, C. P. ; Häussermann, P. ; Hellmich, M. ; Klosterkötter, J. ; Wiltfang, J. ; Maarouf, M. ; Freund, H. J. ; Visser-Vandewalle, V. ; Sturm, V. ; Schulz, R.-J.

2015
Springer Paris

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Please use a persistent id in citations: doi:10.1007/s12603-015-0595-8

Abstract: The progression of Alzheimer’s disease (AD) is associated with impaired nutritional status. New methods, such as deep brain stimulation (DBS), are currently being tested to decrease the progression of AD. DBS is an approved method in the treatment of Parkinson’s disease, and its suitability for the treatment of AD patients is currently under experimental investigation. To evaluate the advantages and disadvantages of this new treatment, it is important to assess potential side effects of DBS regarding the nucleus basalis of Meynert; this new treatment is thought to positively affect cognition and might counteract the deterioration of nutritional status and progressive weight loss observed in AD. This study aims to assess the nutritional status of patients with AD before receiving DBS of the nucleus basalis of Meynert and after 1 year, and to analyze potential associations between changes in cognition and nutritional status.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)

Appears in the scientific report 2015

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Database coverage:
; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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