Journal Article

PreJuSER-3293

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cone contacts, mosaics, and territories of bipolar cells in the mouse retina

Wässle, H. ; Puller, C. ; Müller, F.FZJ* ; Haverkamp, S.

2009
Soc. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/4653  doi:10.1523/JNEUROSCI,4442-08.2009

Abstract: We report a quantitative analysis of the different bipolar cell types of the mouse retina. They were identified in wild-type mice by specific antibodies or in transgenic mouse lines by specific expression of green fluorescent protein or Clomeleon. The bipolar cell densities, their cone contacts, their dendritic coverage, and their axonal tiling were measured in retinal whole mounts. The results show that each and all cones are contacted by at least one member of any given type of bipolar cell (not considering genuine blue cones). Consequently, each cone feeds its light signals into a minimum of 10 different bipolar cells. Parallel processing of an image projected onto the retina, therefore, starts at the first synapse of the retina, the cone pedicle. The quantitative analysis suggests that our proposed catalog of 11 cone bipolar cells and one rod bipolar cell is complete, and all major bipolar cell types of the mouse retina appear to have been discovered.

Keyword(s): J ; bipolar cells (auto) ; convergence (auto) ; divergence (auto) ; cone contacts (auto) ; coverage (auto) ; tiling (auto)

Note: This work was supported by a grant from the Deutsche Forschungsgemeinschaft (FOR 701, PE 38/16-1). We are grateful to Dr. Hannah Monyer and Dr. Dragos Inta for providing the 5-HT3R-EGFP mouse line. We thank B. Marshallsay for technical assistance and I. Odenthal for typing this manuscript.

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Contributing Institute(s):

1. Zelluläre Biophysik (ISB-1)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)
2. Molekulare Magnete (N01)

Appears in the scientific report 2009

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