Journal Article

PreJuSER-3699

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability

Helmstaedter, M. ; Sakmann, B. ; Feldmeyer, D.FZJ*

2009
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhn130

Abstract: For a detailed description of the circuitry of cortical columns at the level of single neurons, it is essential to define the identities of the cell types that constitute these columns. For interneurons (INs), we described 4 "types of axonal projection patterns" in layer 2/3 (L2/3) with reference to the outlines of a cortical column (Helmstaedter et al. 2008a). In addition we quantified the dendritic geometry and electrical excitability of 3 types of the L2/3 INs: "local," "lateral," and "translaminar" inhibitors (Helmstaedter et al. 2008b). Here, we used an iterated cluster analysis (iCA) that combines axonal projection patterns with dendritic geometry and electrical excitability parameters to identify "groups" of INs, from a sample of 39 cells. The iCA defined 9 groups of INs. We propose a hierarchical scheme for identifying L2/3 INs. First, L2/3 INs can be classified as 4 types of axonal projections. Second, L2/3 INs can be subclassified as 9 groups with a high within-group similarity of dendritic, axonal, and electrical parameters. This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns.

Keyword(s): Action Potentials: physiology (MeSH) ; Animals (MeSH) ; Axons: physiology (MeSH) ; Dendrites: physiology (MeSH) ; Excitatory Postsynaptic Potentials: physiology (MeSH) ; Interneurons: cytology (MeSH) ; Interneurons: physiology (MeSH) ; Neural Pathways: cytology (MeSH) ; Neural Pathways: physiology (MeSH) ; Rats (MeSH) ; Rats, Wistar (MeSH) ; Somatosensory Cortex: physiology (MeSH) ; J ; axons (auto) ; barrel cortex (auto) ; cluster analysis (auto) ; dendrites (auto) ; electrical excitability (auto) ; GABAergic interneuron (auto) ; lateral inhibition (auto) ; layer 2 (auto) ; 3 (auto)

Note: This work was supported by the Max-Planck Society.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2009

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