Journal Article

PreJuSER-37257

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The archaeal sensory rhodopsin II/transducer complex: a model for transmembrane signal transfer

Klare, J. P. ; Gordeliy, V. I.FZJ* ; Labahn, J.FZJ* ; Büldt, G.FZJ* ; Steinhoff, H.-J. ; Engelhard, M.

2004
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/S0014-5793(04)00193-0

Abstract: Archaebacterial photoreceptors mediate phototaxis by regulating cell motility through two-component signalling cascades. Homologs of this sensory pathway occur in all three kingdoms of life, most notably in enteric bacteria in which the chemotaxis has been extensively studied. Recent structural and functional studies on the sensory rhodopsin II/transducer complex mediating the photophobic response of Natronomonas pharaonis have yielded new insights into the mechanisms of signal transfer across the membrane. Electron paramagnetic resonance data and the atomic resolution structure of the receptor molecule in complex with the transmembrane segment of its cognate transducer provided a model for signal transfer from the receptor to the cytoplasmic side of the transducer. This mechanism might also be relevant for eubacterial chemoreceptor signalling. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Keyword(s): J ; phoborhodopsin (auto) ; phototaxis (auto) ; chemotaxis (auto) ; signal transduction (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Biologische Strukturforschung (IBI-2)

Research Program(s):

1. Neurowissenschaften (L01)

Appears in the scientific report 2004

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