Journal Article

PreJuSER-50539

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Suspended Nanoporous Membranes as Interfaces for Neuronal Biohybrid Systems

Wolfrum, B.FZJ* ; Mourzina, Y.FZJ* ; Sommerhage, F.FZJ* ; Offenhäusser, A.FZJ*

2006
ACS Publ. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/2127  doi:10.1021/nl052370x

Abstract: A biohybrid system composed of neuronal cells and silicon-supported nanoporous membranes has been designed to facilitate control of the biochemical environment of neuronal networks with cellular resolution. The membranes may exhibit variable pore sizes and interpore distances and are interfaced to a microfluidic device. Different porosity parameters give rise to changes in the transconductance of the nanopores and can therefore be used to control diffusion of molecules through the membranes. It was shown that the porous membranes are biocompatible with primary vertebrate as well as insect neurons. Our results indicate that nanoporous membranes may be used to interface with biological materials in a biohybrid system, for example as an artificial chemical synapse interface.

Keyword(s): Animals (MeSH) ; Cell Line (MeSH) ; Humans (MeSH) ; Microscopy, Electron, Scanning (MeSH) ; Microscopy, Fluorescence (MeSH) ; Models, Biological (MeSH) ; Nanostructures: chemistry (MeSH) ; Nanostructures: ultrastructure (MeSH) ; Neurons: metabolism (MeSH) ; Porosity (MeSH) ; Rats (MeSH) ; Silicon: chemistry (MeSH) ; Synapses: metabolism (MeSH) ; Silicon ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Institut für Bio- und Chemosensoren (ISG-2)
2. Center of Nanoelectronic Systems for Information Technology (CNI)
3. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Grundlagen für zukünftige Informationstechnologien (P42)

Appears in the scientific report 2006

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Database coverage:

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