Journal Article

PreJuSER-53548

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Detecting the effect of very low amounts of penetrants in lipid bilayers using Raman spectroscopy

Meier, R. J. ; Csiszár, A.FZJ* ; Klumpp, E.FZJ*

2006
Soc. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/799  doi:10.1021/jp0615757

Abstract: We show that, by the influence on the gauche content in the acyl chains, the effect of very low concentrations (order 10(-2) %) of penetrants (here 2,4-dichlorophenol) in lipid bilayers (here dipalmitoyl-glycerophosphatidylcholine) can be experimentally seen in the Raman spectra. The observed effects suggest increased order and are in accordance with previous X-ray diffraction and calorimetric data. These findings show great promise for studying in situ the effect of low amounts of various small molecules on cell membranes using Raman spectroscopy.

Keyword(s): 1,2-Dipalmitoylphosphatidylcholine (MeSH) ; Lipid Bilayers: metabolism (MeSH) ; Organic Chemicals: pharmacokinetics (MeSH) ; Permeability: drug effects (MeSH) ; Phase Transition: drug effects (MeSH) ; Spectrum Analysis, Raman (MeSH) ; Lipid Bilayers ; Organic Chemicals ; 1,2-Dipalmitoylphosphatidylcholine ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Agrosphäre (ICG-IV)
2. Biologische Schichten (ISG-4)

Research Program(s):

1. Terrestrische Umwelt (P24)
2. Kondensierte Materie (P54)

Appears in the scientific report 2006

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Database coverage:

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