Journal Article

PreJuSER-53581

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Evidence for activator and repressor functions of the response regulator MtrA from Corynebacterium glutamicum

Brocker, M.FZJ* ; Bott, M.FZJ*

2006
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/596  doi:10.1111/j.1574-6968.2006.00456.x

Abstract: Previous analysis of a Corynebacterium glutamicum Delta mtrAB mutant showed that the MtrAB two-component signal transduction system influences the expression of genes involved in cell wall metabolism or osmoregulation, but it remained unknown whether this influence is direct or indirect. In order to identify the direct target genes of the response regulator MtrA, chromatin immunoprecipitation as a genome-wide approach and DNA affinity chromatography as a gene-specific approach were used. The results indicate that mepA and nlpC, both encoding putative cell wall peptidases, are directly repressed by MtrA, whereas proP and betP, both encoding carriers for compatible solutes, are directly activated by MtrA.

Keyword(s): ATP-Binding Cassette Transporters: metabolism (MeSH) ; ATP-Binding Cassette Transporters: physiology (MeSH) ; Bacterial Proteins: metabolism (MeSH) ; Bacterial Proteins: physiology (MeSH) ; Corynebacterium glutamicum: genetics (MeSH) ; Corynebacterium glutamicum: metabolism (MeSH) ; Corynebacterium glutamicum: ultrastructure (MeSH) ; Gene Expression Regulation, Bacterial (MeSH) ; Repressor Proteins: genetics (MeSH) ; Repressor Proteins: physiology (MeSH) ; Signal Transduction: physiology (MeSH) ; Transcription Factors: genetics (MeSH) ; Transcription Factors: metabolism (MeSH) ; Transcriptional Activation: physiology (MeSH) ; ATP-Binding Cassette Transporters ; Bacterial Proteins ; MtrA protein, Bacteria ; Repressor Proteins ; Transcription Factors ; J ; Corynebacterium glutamicum (auto) ; two-component system (auto) ; sensor kinase (auto) ; response regulator (auto) ; MtrA (auto) ; MtrB (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Biotechnologie 1 (IBT-1)

Research Program(s):

1. Biotechnologie (PBT)

Appears in the scientific report 2006
Notes: The definitive version is available via www.blackwell-synergy.com at dx.doi.org/10.1111/j.1574-6968.2006.00456.x .

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Database coverage:

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