Journal Article

PreJuSER-544

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Resolution enhancement in MRI of laser polarized 3He by control of diffusion

Agulles-Pedrós, L. ; Acosta, R. H. ; Blümler, P.FZJ* ; Spiess, H. W.

2009
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jmr.2008.12.003

Abstract: Diffusion of atoms or molecules in presence of magnetic field gradients not only attenuates the NMR signal but also leads to distortions close to restricting boundaries. This phenomenon is most evident in imaging with laser polarized (LP) noble gases. Diffusion of gases can be manipulated, however, by admixing inert gases of different molecular weight. In this work we analyze the effect of mixing LP-(3)He with SF(6) on the image quality of a phantom consisting of an arrangement of capillaries with different diameters. Admixing buffer gases of higher molecular weight changes the contrast and offers a means to record images with high spatial and time resolution. Additionally we demonstrate how distortions due to edge enhancement can be reduced even for long timed MRI-sequences.

Keyword(s): Diffusion (MeSH) ; Diffusion Magnetic Resonance Imaging: methods (MeSH) ; Gases: chemistry (MeSH) ; Gases: radiation effects (MeSH) ; Helium: analysis (MeSH) ; Helium: chemistry (MeSH) ; Image Enhancement: methods (MeSH) ; Isotopes: analysis (MeSH) ; Isotopes: chemistry (MeSH) ; Lasers (MeSH) ; Magnetic Resonance Spectroscopy: methods (MeSH) ; Gases ; Isotopes ; Helium ; J ; Gas MRI (auto) ; Restricted diffusion (auto) ; Edge enhancement (auto) ; Motional averaging (auto) ; Contrast (auto) ; Hyperpolarized gases (auto)

Note: The authors want to thank Manfred Hehn and Hanspeter Raich for their help in the design and construction of the gas handling system at the MPI-P and jorg Schmiecleskarnp for the <SUP>3</SUP>He hyperpolarization. Financial support by DFG (Forschergruppe "Bildgestatzte zeitliche und regionale Analyse der Ventilations - Peifusionsverhdltnisse in der Lunge", grant # FOR 474) and a special grant of the Max Planck society made this work possible. Finally, we want to acknowledge the Partner Group for NMR Spectroscopy with High Spin Polarization FaMAF-MPIP.

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Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2009

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