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| Hauptseite > Publikationsdatenbank > Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains |
| Hauptseite > Publikationsdatenbank > Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains |
| Journal Article | PreJuSER-55020 |
; ; ;
2006
BioMed Central
London
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Please use a persistent id in citations: doi:10.1007/s11373-005-9043-9
Abstract: The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.
Keyword(s): Amino Acid Sequence (MeSH) ; Antigens, CD: chemistry (MeSH) ; Cell Adhesion Molecules: chemistry (MeSH) ; Cloning, Molecular (MeSH) ; Humans (MeSH) ; Immunoglobulins: chemistry (MeSH) ; Integrins: chemistry (MeSH) ; Intercellular Adhesion Molecule-1: chemistry (MeSH) ; Interleukin-1: chemistry (MeSH) ; Lymphocyte Function-Associated Antigen-1: chemistry (MeSH) ; Models, Molecular (MeSH) ; Molecular Sequence Data (MeSH) ; Open Reading Frames (MeSH) ; Protein Structure, Secondary (MeSH) ; Protein Structure, Tertiary (MeSH) ; SARS Virus: chemistry (MeSH) ; Viral Matrix Proteins: chemistry (MeSH) ; Viral Proteins: chemistry (MeSH) ; Antigens, CD ; Cell Adhesion Molecules ; Immunoglobulins ; Integrins ; Interleukin-1 ; Lymphocyte Function-Associated Antigen-1 ; Viral Matrix Proteins ; Viral Proteins ; sars7a protein, SARS virus ; Intercellular Adhesion Molecule-1 ; ICAM2 protein, human ; J ; 7a (auto) ; coronavirus (auto) ; immunoglobulin fold (auto) ; integrin (auto) ; LFA-1 (auto) ; NMR structure determination (auto) ; ORF8 (auto) ; SARS (auto) ; U122 (auto) ; X4 (auto)
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