Journal Article

FZJ-2016-03990

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spatial normalization of brain images and beyond.

Mangin, J.-F. (Corresponding author) ; Lebenberg, J. ; Lefranc, S. ; Labra, N. ; Auzias, G. ; Labit, M. ; Guevara, M. ; Mohlberg, H.FZJ* ; Roca, P. ; Guevara, P. ; Dubois, J. ; Leroy, F. ; Dehaene-Lambertz, G. ; Cachia, A. ; Dickscheid, T.FZJ* ; Coulon, O. ; Poupon, C. ; Rivière, D. ; Amunts, K.FZJ* ; Sun, Z. Y.

2016
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.media.2016.06.008

Abstract: The deformable atlas paradigm has been at the core of computational anatomy during the last two decades. Spatial normalization is the variant endowing the atlas with a coordinate system used for voxel-based aggregation of images across subjects and studies. This framework has largely contributed to the success of brain mapping. Brain spatial normalization, however, is still ill-posed because of the complexity of the human brain architecture and the lack of architectural landmarks in standard morphological MRI. Multi-atlas strategies have been developed during the last decade to overcome some difficulties in the context of segmentation. A new generation of registration algorithms embedding architectural features inferred for instance from diffusion or functional MRI is on the verge to improve the architectural value of spatial normalization. A better understanding of the architectural meaning of the cortical folding pattern will lead to use some sulci as complementary constraints. Improving the architectural compliance of spatial normalization may impose to relax the diffeomorphic constraint usually underlying atlas warping. A two-level strategy could be designed: in each region, a dictionary of templates of incompatible folding patterns would be collected and matched in a way or another using rare architectural information, while individual subjects would be aligned using diffeomorphisms to the closest template. Manifold learning could help to aggregate subjects according to their morphology. Connectivity-based strategies could emerge as an alternative to deformation-based alignment leading to match the connectomes of the subjects rather than images.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP - The Human Brain Project (604102) (604102)

Appears in the scientific report 2016

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Database coverage:
; Current Contents - Engineering, Computing and Technology ; IF < 5 ; JCR ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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