Journal Article

FZJ-2016-06702

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Amphiphilic Triblock Copolymers from Poly(2-oxazoline) with Different Hydrophobic Blocks: Changes of the Micellar Structures upon Addition of a Strongly Hydrophobic Cancer Drug

Jaksch, S.FZJ* ; Schulz, A. ; Di, Z. ; Luxenhofer, R. ; Jordan, R. ; Papadakis, C. M. (Corresponding author)

2016
Wiley-VCH Weinheim

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/macp.201500465

Abstract: AbstractimageAmphiphilic triblock copolymers with poly(2-methyl-2-oxazoline) (MeOx) end blocks and a poly(2-n-butyl-2-oxazoline) (nBuOx) middle block have been found to solubilize large amounts of the cancer drug paclitaxel (PTX) whereas this is not the case when the middle block is more hydrophobic, such as poly(2-n-nonyl-2-oxazoline) (NOx) (Schulz et al., ACS Nano2014, 8, 2686). To further elucidate the origin of this behavior, dilute aqueous solutions (5–10 mg mL−1) of these two copolymers have been investigated by small-angle neutron scattering (SANS), both in the absence and presence of PTX. Whereas PMeOx-b-PNOx-b-PMeOx forms mainly worm-like micelles coexisting with large aggregates, spherical micelles are predominant in PMeOx-b-PnBuOx-b-PMeOx. Already small PTX concentrations lead to shape changes in PMeOx-b-PNOx-b-PMeOx toward spherical micelles. In contrast, changes in the aggregation behavior of PMeOx-b-PnBuOx-b-PMeOx are only observed at higher PTX concentrations with a transformation into raspberry-like particles, which may explain the high PTX loading capacity of PMeOx-b-PnBuOx-b-PMeOx micelles.

Keyword(s): Health and Life (1st) ; Medicine (2nd) ; Soft Condensed Matter (2nd)

---

Contributing Institute(s):

1. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
2. Neutronenstreuung (Neutronenstreuung ; JCNS-1)

Research Program(s):

1. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)
2. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)

Experiment(s):

1. KWS-1: Small angle scattering diffractometer (NL3b)

Appears in the scientific report 2016

---

Database coverage:
; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---