Journal Article

FZJ-2016-06974

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Microstructural proliferation in human Cortex is coupled with the development of face processing

Gomez, J. ; Barnett, M. A. ; Natu, V. ; Mezer, A. ; Palomero-Gallagher, N.FZJ* ; Weiner, K. S. ; Amunts, K.FZJ* ; Zilles, K.FZJ* ; Grill-Spector, K. (Corresponding author)

2017
American Association for the Advancement of Science64196 Washington, DC [u.a.]

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Please use a persistent id in citations: doi:10.1126/science.aag0311

Abstract: How does cortical tissue change as brain function and behavior improve from childhood to adulthood? By combining quantitative and functional magnetic resonance imaging in children and adults, we find differential development of high-level visual areas that are involved in face and place recognition. Development of face-selective regions, but not place-selective regions, is dominated by microstructural proliferation. This tissue development is correlated with specific increases in functional selectivity to faces, as well as improvements in face recognition, and ultimately leads to differentiated tissue properties between face- and place-selective regions in adulthood, which we validate with postmortem cytoarchitectonic measurements. These data suggest a new model by which emergent brain function and behavior result from cortical tissue proliferation rather than from pruning exclusively.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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