The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization

GENON, Sarah; Hoffstaedter, Felix; Jiang, Tianzi; Cieslik, Edna; Li, Hai; Müller, Veronika; Laird, Angela R.; Grefkes, Christian; Reid, Andrew; Langner, Robert; Amunts, Katrin; Fox, Peter T.; Eickhoff, Simon; Fan, Lingzhong

doi:10.1016/j.neuroimage.2017.02.034

Journal Article

FZJ-2017-02052

The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization

GENON, S. (Corresponding author)FZJ* ; Reid, A.FZJ* ; Li, H. ; Fan, L. ; Müller, V.FZJ* ; Cieslik, E.FZJ* ; Hoffstaedter, F.FZJ* ; Langner, R.FZJ* ; Grefkes, C.FZJ* ; Laird, A. R. ; Fox, P. T. ; Jiang, T. ; Amunts, K.FZJ* ; Eickhoff, S.FZJ*

2018
Academic Press Orlando, Fla.

NeuroImage 170, 400-411 (2018) [10.1016/j.neuroimage.2017.02.034]

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Please use a persistent id in citations: http://hdl.handle.net/2128/17740 doi:10.1016/j.neuroimage.2017.02.034

Abstract: Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.

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