Journal Article

FZJ-2017-02135

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity

Genon, S.FZJ* ; Li, H. ; Fan, L. ; Müller, V. I. ; Cieslik, E.FZJ* ; Hoffstaedter, F.FZJ* ; Reid, A. T. ; Langner, R.FZJ* ; Grefkes, C.FZJ* ; Fox, P. T. ; Moebus, S. ; Caspers, S.FZJ* ; Amunts, K.FZJ* ; Jiang, T. ; Eickhoff, S. (Corresponding author)FZJ*

2017
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhw065

Abstract: The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)
2. HBP - Human Brain Project (284941) (284941)

Appears in the scientific report 2017

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Database coverage:
; Allianz-Lizenz / DFG ; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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