Journal Article

FZJ-2017-03997

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spike Synchronization and Rate Modulation Differentially Involved in Motor Cortical Function

Riehle, A. (Corresponding author) ; Grün, S.FZJ* ; Diesmann, M.FZJ* ; Aertsen, A.

1997
American Association for the Advancement of Science64196 Washington, DC [u.a.]

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Please use a persistent id in citations: doi:10.1126/science.278.5345.1950

Abstract: It is now commonly accepted that planning and execution of movements are based on distributed processing by neuronal populations in motor cortical areas. It is less clear, though, how these populations organize dynamically to cope with the momentary computational demands. Simultaneously recorded activities of neurons in the primary motor cortex of monkeys during performance of a delayed-pointing task exhibited context-dependent, rapid changes in the patterns of coincident action potentials. Accurate spike synchronization occurred in relation to external events (stimuli, movements) and was commonly accompanied by discharge rate modulations but without precise time locking of the spikes to these external events. Spike synchronization also occurred in relation to purely internal events (stimulus expectancy), where firing rate modulations were distinctly absent. These findings indicate that internally generated synchronization of individual spike discharges may subserve the cortical organization of cognitive motor processes.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)
3. DFG project 238707842 - Kausative Mechanismen mesoskopischer Aktivitätsmuster in der auditorischen Kategorien-Diskrimination (238707842) (238707842)
4. BMBF-01GQ1114 - Einfluss von top-down Signalen auf den autonomen Sehvorgang - Multiskalen Analyse von massiv-parallelen Multi-Area-Daten des visuellen Pfades (BMBF-01GQ1116) (BMBF-01GQ1116)
5. SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) (HGF-SMHB-2013-2017)

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