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@ARTICLE{TiruttaniSubhramanyam:834239,
      author       = {Tiruttani Subhramanyam, Udaya Kumar and Kubicek, Jan and
                      Eidhoff, Ulf Benno and Labahn, Jörg},
      title        = {{S}tructural basis for the regulatory interactions of
                      proapoptotic {P}ar-4},
      journal      = {Cell death and differentiation},
      volume       = {24},
      issn         = {1350-9047},
      address      = {Houndmills, Basingstoke},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2017-04221},
      pages        = {1540–1547},
      year         = {2017},
      abstract     = {Par-4 is a unique proapoptotic protein with the ability to
                      induce apoptosis selectively in cancer cells. The X-ray
                      crystal structure of the C-terminal domain of Par-4
                      (Par-4CC), which regulates its apoptotic function, was
                      obtained by MAD phasing. Par-4 homodimerizes by forming a
                      parallel coiled-coil structure. The N-terminal half of
                      Par-4CC contains the homodimerization subdomain. This
                      structure includes a nuclear export signal (Par-4NES)
                      sequence, which is masked upon dimerization indicating a
                      potential mechanism for nuclear localization. The
                      heteromeric-interaction models specifically showed that
                      charge interaction is an important factor in the stability
                      of heteromers of the C-terminal leucine zipper subdomain of
                      Par-4 (Par-4LZ). These heteromer models also displayed NES
                      masking capacity and therefore the ability to influence
                      intracellular localization.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000407506500009},
      pubmed       = {pmid:28622290},
      doi          = {10.1038/cdd.2017.76},
      url          = {https://juser.fz-juelich.de/record/834239},
}