Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist.

Martin, Jessica; Treutlein, Jens; Nöthen, Markus M; Witt, Stephanie H; Forstner, Andreas J; Streit, Fabian; Frank, Josef; Schulze, Thomas G; Degenhardt, Franziska; Rietschel, Marcella; Strohmaier, Jana; Cichon, Sven; Lang, Maren

doi:10.1097/YPG.0000000000000182

Journal Article

FZJ-2017-06029

Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist.

Martin, J. (Corresponding author) ; Streit, F. (Corresponding author) ; Treutlein, J. ; Lang, M. ; Frank, J. ; Forstner, A. J. ; Degenhardt, F. ; Witt, S. H. ; Schulze, T. G. ; Cichon, S.FZJ* ; Nöthen, M. M. ; Rietschel, M. ; Strohmaier, J.

2017
Lippincott Williams & Wilkins Hagerstown, Md.

Psychiatric genetics 27(5), 187-196 (2017) [10.1097/YPG.0000000000000182]

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Please use a persistent id in citations: http://hdl.handle.net/2128/15574 doi:10.1097/YPG.0000000000000182

Abstract: Major depression disorder (MDD) is a complex neuropsychiatric disorder and an increasing number of genetic risk variants are being identified. Investigation of their influence in the general population requires accurate and efficient assessment of depressive symptoms. Here, clinical interviews conducted by clinicians are the gold standard. We investigated whether valid and reliable clinical phenotypes can be obtained efficiently using self-administered instruments. Lifetime depressive symptoms and lifetime MDD diagnosis were assessed in 464 population-based individuals using a clinical interview and a structured, self-administered checklist. Analyses were carried out of the following: (i) intraclass correlations (ICC) between checklist and interview; (ii) sensitivity/specificity of the checklist; and (iii) the association of interview and checklist with a positive family history of MDD (FH-MDD+). The correspondence of the self-administered checklist with the clinical interview was good for most depressive symptoms (ICC=0.60-0.80) and moderate for MDD diagnosis (ICC=0.45). With the consecutive inclusion of MDD diagnostic criteria, sensitivity decreased from 0.67 to 0.46, whereas specificity remained high (0.95). For checklist and interview, strong associations were found between FH-MDD+ and most depressive symptoms and MDD diagnosis (all odds ratio≥1.83). The self-administered checklist showed high reliability for both the assessment of lifetime depressive symptoms and screening for individuals with no lifetime diagnosis of MDD. However, attention is warranted when the aim is to identify MDD cases. The positive association between depressive symptomatology and FH-MDD+ indicates the usefulness of both instruments to assess patients in genetic studies. Our data suggest that the more time-efficient and cost-efficient self-administered instruments also allow for the assessment of depressive symptoms accurate enough to investigate the influence of MDD genetic risk variants in the general population.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

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