Journal Article

FZJ-2018-04700

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

Mattes, B. ; Dang, Y. ; Greicius, G. ; Kaufmann, L. T. ; Prunsche, B. ; Rosenbauer, J.FZJ* ; Stegmaier, J. ; Mikut, R. ; Özbek, S. ; Nienhaus, G. U. ; Schug, A.FZJ* ; Virshup, D. M. ; Scholpp, S. (Corresponding author)

2018
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/19571  doi:10.7554/eLife.36953

Abstract: Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that regulate the exchange of signaling molecules and their receptors within tissues. However, how cytoneme formation is regulated remains unclear. Here, we show that Wnt/PCP autocrine signaling controls the emergence of cytonemes, and that cytonemes subsequently control paracrine Wnt/β-catenin signal activation. Upon binding of the Wnt family member Wnt8a, the receptor tyrosine kinase Ror2 gets activated. Ror2/PCP signaling leads to induction of cytonemes, which mediate transport of Wnt8a to neighboring cells. In the Wnt receiving cells, Wnt8a on cytonemes triggers Wnt/β-catenin-dependent gene transcription and proliferation. We show that cytoneme-based Wnt transport operates in diverse processes, including zebrafish development, the murine intestinal crypt, and human cancer organoids, demonstrating that Wnt transport by cytonemes and its control via the Ror2 pathway is highly conserved in vertebrates.

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Contributing Institute(s):

1. John von Neumann - Institut für Computing (NIC)
2. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
2. PhD no Grant - Doktorand ohne besondere Förderung (PHD-NO-GRANT-20170405) (PHD-NO-GRANT-20170405)

Appears in the scientific report 2018

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Database coverage:
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