Journal Article

FZJ-2018-06858

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effective connectivity of the anterior hippocampus predicts recollection confidence during natural memory retrieval

Ren, Y. ; Nguyen, V. T. ; Sonkusare, S. ; Lv, J. ; Pang, T. ; Guo, L. ; Eickhoff, S.FZJ* ; Breakspear, M. ; Guo, C. C. (Corresponding author)

2018
Nature Publishing Group UK [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/20499  doi:10.1038/s41467-018-07325-4

Abstract: Human interactions with the world are influenced by memories of recent events. This effect, often triggered by perceptual cues, occurs naturally and without conscious effort. However, the neuroscience of involuntary memory in a dynamic milieu has received much less attention than the mechanisms of voluntary retrieval with deliberate purpose. Here, we investigate the neural processes driven by naturalistic cues that relate to, and presumably trigger the retrieval of recent experiences. Viewing the continuation of recently viewed clips evokes greater bilateral activation in anterior hippocampus, precuneus and angular gyrus than naïve clips. While these regions manifest reciprocal connectivity, continued viewing specifically modulates the effective connectivity from the anterior hippocampus to the precuneus. The strength of this modulation predicts participants' confidence in later voluntary recall of news details. Our study reveals network mechanisms of dynamic, involuntary memory retrieval and its relevance to metacognition in a rich context resembling everyday life.

Note: Y.R. performed the experiment, preprocessed/analysed the data and prepared/wrote the manuscript. V.T.N. designed the experiment, collected/preprocessed the data, and revised the manuscript. S.S. and J.L. collected/preprocessed the data and revised the manuscript. T.P. analysed the news clips and revised the manuscript. L.G. supported idea and revised the manuscript. C.C.G, V.T.N, S.B.E. and M.B. designed the experiment and revised the manuscript. C.C.G. initiated and supervised the study, discussed and interpreted the results, as well as prepared/revised the manuscript.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)

Appears in the scientific report 2018

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