Journal Article

FZJ-2018-07399

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Microbial production of natural and non‐natural monolignols with Escherichia coli

Aschenbrenner, J. ; Marx, P.FZJ* ; Pietruszka, J.FZJ* ; Marienhagen, J. (Corresponding author)FZJ*

2019
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/23484  doi:10.1002/cbic.201800673

Abstract: Phenylpropanoids and phenylpropanoid‐derived plant polyphenols find numerous applications in the food and pharmaceutical industries. In recent years, several microbial platform organisms have been engineered towards producing such compounds. However, for the most part, microbial (poly)phenol production is inspired by nature, so naturally occurring compounds have predominantly been produced to date.Here we have taken advantage of the promiscuity of the enzymes involved in phenylpropanoid synthesis and exploited the versatility of an engineered Escherichia coli strain harboring a synthetic monolignol pathway to convert supplemented natural and unnatural phenylpropenoic acids into their corresponding monolignols. The performed biotransformations showed that this strain is able to catalyze the stepwise reduction of chemically interesting unnatural phenylpropenoic acids such as 3,4,5‐trimethoxycinnamic acid, 5‐bromoferulic acid, 2‐nitroferulic acid, and a “bicyclic” p‐coumaric acid derivative, in addition to six naturally occurring phenylpropenoic acids.

Note: Biotechnologie 1

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Contributing Institute(s):

1. Biotechnologie (IBG-1)
2. Institut für Bioorganische Chemie (HHUD) (IBOC)

Research Program(s):

1. 583 - Innovative Synergisms (POF3-583) (POF3-583)

Appears in the scientific report 2019

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Database coverage:
; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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