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000859131 1001_ $$0P:(DE-Juel1)168292$$aAchtsnicht, Stefan$$b0
000859131 245__ $$a3D Printed Modular Immunofiltration Columns for Frequency Mixing-Based Multiplex Magnetic Immunodetection
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000859131 520__ $$aFor performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.
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000859131 7001_ $$0P:(DE-HGF)0$$aTödter, Julia$$b1
000859131 7001_ $$0P:(DE-HGF)0$$aNiehues, Julia$$b2
000859131 7001_ $$0P:(DE-HGF)0$$aTelöken, Matthias$$b3
000859131 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b4
000859131 7001_ $$0P:(DE-Juel1)128697$$aKrause, Hans-Joachim$$b5$$eCorresponding author
000859131 7001_ $$00000-0002-2490-3728$$aSchröper, Florian$$b6$$eCorresponding author
000859131 773__ $$0PERI:(DE-600)2052857-7$$a10.3390/s19010148$$gVol. 19, no. 1, p. 148 -$$n1$$p148 -$$tSensors$$v19$$x1424-8220$$y2019
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