Journal Article/Contribution to a conference proceedings

FZJ-2019-02960

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex

Yakoubi, R. (Corresponding author)FZJ* ; Rollenhagen, A.FZJ* ; von Lehe, M. ; Miller, D. ; Walkenfort, B. ; Hasenberg, M. ; Sätzler, K. ; Lübke, J. H.FZJ*

2019
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/27299  doi:10.7554/eLife.48373

Abstract: Synapses are fundamental building blocks controlling and modulating the 'behavior' of brain networks. How their structural composition, most notably their quantitative morphology underlie their computational properties remains rather unclear, particularly in humans. Here, excitatory synaptic boutons (SBs) in layer 4 (L4) of the temporal lobe neocortex (TLN) were quantitatively investigated. Biopsies from epilepsy surgery were used for fine-scale and tomographic electron microscopy (EM) to generate 3D-reconstructions of SBs. Particularly, the size of active zones (AZs) and that of the three functionally defined pools of synaptic vesicles (SVs) were quantified. SBs were comparatively small (~2.50 μm2), with a single AZ (~0.13 µm2); preferentially established on spines. SBs had a total pool of ~1800 SVs with strikingly large readily releasable (~ 20), recycling (~ 80) and resting pools (~850). Thus, human L4 SBs may act as 'amplifiers' of signals from the sensory periphery, integrate, synchronize and modulate intra- and extracortical synaptic activity.

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Contributing Institute(s):

1. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 899 - ohne Topic (POF3-899) (POF3-899)

Appears in the scientific report 2019

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Database coverage:
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