Journal Article

FZJ-2019-05723

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Perfusion weighted imaging using combined gradient/spin echo EPIK: Brain tumour applications in hybrid MR-PET

Shah, N. J. (Corresponding author)FZJ* ; da Silva, N. A. ; Yun, S. D.FZJ*

2021
Wiley-Liss New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/28500  doi:10.1002/hbm.24537

Abstract: Advanced perfusion‐weighted imaging (PWI) methods that combine gradient echo (GE) and spin echo (SE) data are important tools for the study of brain tumours. In PWI, single‐shot, EPI‐based methods have been widely used due to their relatively high imaging speed. However, when used with increasing spatial resolution, single‐shot EPI methods often show limitations in whole‐brain coverage for multi‐contrast applications. To overcome this limitation, this work employs a new version of EPI with keyhole (EPIK) to provide five echoes: two with GEs, two with mixed GESE and one with SE; the sequence is termed “GESE‐EPIK.” The performance of GESE‐EPIK is evaluated against its nearest relative, EPI, in terms of the temporal signal‐to‐noise ratio (tSNR). Here, data from brain tumour patients were acquired using a hybrid 3T MR‐BrainPET scanner.GESE‐EPIK resulted in reduced susceptibility artefacts, shorter TEs for the five echoes and increased brain coverage when compared to EPI. Moreover, compared to EPI, EPIK achieved a comparable tSNR for the first and second echoes and significantly higher tSNR for other echoes.A new method to obtain multi‐echo GE and SE data with shorter TEs and increased brain coverage is demonstrated. As proposed here, the workflow can be shortened and the integration of multimodal clinical MR‐PET studies can be facilitated.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Jara-Institut Quantum Information (INM-11)
3. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)
2. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2021

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Database coverage:
; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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