Journal Article

FZJ-2020-00301

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Automated and Optimally FRET-Assisted Structural Modeling

Dimura, M. ; Ottavio Peulen, T. ; Sanabria, H. ; Rodnin, D. ; Hemmen, K. ; Seidel, C. A. M. (Corresponding author)Extern* ; Gohlke, H. (Corresponding author)FZJ*

2019
Soc. Bethesda, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/23911  doi:10.1016/j.bpj.2018.11.1815

Abstract: FRET experiments can yield state-specific structural information on complex dynamic biomolecular assemblies. However, FRET experiments need to be combined with computer simulations to overcome their sparsity. We introduce (i) an automated FRET experiment design tool determining optimal FRET pairs for structural modeling, (ii) a protocol for efficient FRET-assisted computational structural modeling at multiple scales, and (iii) a quantitative quality estimate for judging the accuracy of determined structures. We tested against simulated and experimental data.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2019

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Database coverage:
; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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