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@ARTICLE{Bscher:873868,
      author       = {Büscher, Tobias and Ganai, Nirmalendu and Gompper, Gerhard
                      and Elgeti, Jens},
      title        = {{T}issue evolution: {M}echanical interplay of adhesion,
                      pressure, and heterogeneity},
      journal      = {New journal of physics},
      volume       = {22},
      issn         = {1367-2630},
      address      = {[London]},
      publisher    = {IOP},
      reportid     = {FZJ-2020-01060},
      pages        = {033048},
      year         = {2020},
      abstract     = {The evolution of various competing cell types in tissues,
                      and the resulting persistent tissue population, is studied
                      numerically and analytically in a particle-based model of
                      active tissues. Mutations change the properties of cells in
                      various ways, including their mechanical properties. Each
                      mutation results in an advantage or disadvantage to grow in
                      the competition between different cell types. While changes
                      in signaling processes and biochemistry play an important
                      role, we focus on changes in the mechanical properties by
                      studying the result of variation of growth force and
                      adhesive cross-interactions between cell types. For
                      independent mutations of growth force and adhesion strength,
                      the tissue evolves towards cell types with high growth force
                      and low internal adhesion strength, as both increase the
                      homeostatic pressure. Motivated by biological evidence, we
                      postulate a coupling between both parameters, such that an
                      increased growth force comes at the cost of a higher
                      internal adhesion strength or vice versa. This tradeoff
                      controls the evolution of the tissue, ranging from
                      unidirectional evolution to very heterogeneous and dynamic
                      populations. The special case of two competing cell types
                      reveals three distinct parameter regimes: Two in which one
                      cell type outcompetes the other, and one in which both cell
                      types coexist in a highly mixed state. Interestingly, a
                      single mutated cell alone suffices to reach the mixed state,
                      while a finite mutation rate affects the results only
                      weakly. Finally, the coupling between changes in growth
                      force and adhesion strength reveals a mechanical explanation
                      for the evolution towards intra-tumor heterogeneity, in
                      which multiple species coexist even under a constant
                      evolutianary pressure.},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / Growth and
                      dynamics of tissues $(jics23_20171101)$},
      pid          = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jics23_20171101$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000522259900001},
      doi          = {10.1088/1367-2630/ab74a5},
      url          = {https://juser.fz-juelich.de/record/873868},
}