Journal Article

FZJ-2020-01689

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png pH-Induced reorientation of cytochrome c on silica nanoparticles

Meissner, J. ; Wu, Y. ; Jestin, J. ; Shelton, W. A. ; Findenegg, G. H. ; Bharti, B. (Corresponding author)

2019
Royal Soc. of Chemistry London

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Please use a persistent id in citations: http://hdl.handle.net/2128/24651  doi:10.1039/C8SM01909F

Abstract: The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.

Keyword(s): Health and Life (1st) ; Soft Condensed Matter (2nd) ; Medicine (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS-FRM-II)
2. Neutronenstreuung (JCNS-1)
3. Heinz Maier-Leibnitz Zentrum (MLZ)

Research Program(s):

1. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)
2. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)

Experiment(s):

1. KWS-1: Small angle scattering diffractometer (NL3b)

Appears in the scientific report 2020

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Database coverage:
; ; Allianz-Lizenz / DFG ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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