Characteristic Frequencies and Times, Signal-to-Noise Ratio and Light Illumination Studies in Nanowire FET Biosensors : Invited paper

Vitusevich, Svetlana

doi:10.1109/UkrMW49653.2020.9252698

Contribution to a conference proceedings/Journal Article

FZJ-2020-04528

Characteristic Frequencies and Times, Signal-to-Noise Ratio and Light Illumination Studies in Nanowire FET Biosensors : Invited paper

Vitusevich, S. (Corresponding author)FZJ*

2020
Inst. of Electr. and Electronics Engineers New York, N.Y.

2020 IEEE Ukrainian Microwave Week (UkrMW), Kharkiv, Ukraine, 21 Sep 2020 - 25 Sep 2020 ... IEEE International Symposium on Circuits and Systems proceedings 9252698, 580-585 (2020) [10.1109/UkrMW49653.2020.9252698]

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Please use a persistent id in citations: doi:10.1109/UkrMW49653.2020.9252698

Abstract: The detection of cardiac biomolecules is of paramount importance for the prospects of fast medical diagnostics of cardiovascular diseases. Silicon nanowire field-effect transistors (NW FETs) are perfect candidates for (bio)sensing studies due to their tremendous sensitivity to changes in surface charge. We present the results of an investigation of transport, fluctuation and modulation phenomena with certain characteristic times in n+-p-n+ liquid-gated field-effect transistors (FETs) and compare them with those of p+-p-p+ structures. We reveal the gate coupling effect to be a tool for influencing the channel noise mechanism. n+-p-n+ liquid-gated FETs demonstrate higher signal-to-noise ratios (SNRs) compared to p+-p-p+ structures. We show the results of the influence of light waves on the electrical properties of NW FET structures and of studying modulation phenomena in these structures. Excitation of NW samples by light waves allows the effective control of conductance in nanowire channels. Noise spectra and time-dependent modulations of the drain current show promising prospects for enhancing the sensitivity and SNR of nanowire biosensors. The direct translation of periodical signals at a frequency around 1 kHz from the biological object into surface potential changes, caused by interaction with cardiac cells, enables the highly sensitive monitoring of cell dynamic activity before and after pharmacological treatments. Electrical properties of the fabricated Si NW FETs demonstrate high sensitivity for the detection of human C-reactive protein (CRP) – a biomolecule which has recently emerged as a reliable biomarker used in clinical practice for predicting and tracking the state of cardiovascular diseases. The response of the sensor to different concentrations of target CRP molecules, which represent predictable cardio-biomarkers, is studied. Moreover, we reveal that the periodical modulation of drain current due to the single-trap effect may be used to achieve enhanced sensitivity of biosensors. The results are promising for cost-efficient lab-on-chip monitoring, which is especially necessary in the case of acute cardiovascular diseases, where every minute is critical for saving life.

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