Journal Article

FZJ-2020-04911

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A computational model‐based analysis of basal ganglia pathway changes in Parkinson’s disease inferred from resting‐state fMRI

Maith, O.FZJ* ; Villagrasa Escudero, F. ; Dinkelbach, H. Ü. ; Baladron, J. ; Horn, A. ; Irmen, F. ; Kühn, A. A. ; Hamker, F. H. (Corresponding author)

2021
Wiley Oxford [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/28911  doi:10.1111/ejn.14868

Abstract: Previous computational model-based approaches for understanding the dynamic changes related to Parkinson's disease made particular assumptions about Parkinson's disease-related activity changes or specified dopamine-dependent activation or learning rules. Inspired by recent model-based analysis of resting-state fMRI, we have taken a data-driven approach. We fit the free parameters of a spiking neuro-computational model to match correlations of blood oxygen level-dependent signals between different basal ganglia nuclei and obtain subject-specific neuro-computational models of two subject groups: Parkinson patients and matched controls. When comparing mean firing rates at rest and connectivity strengths between the control and Parkinsonian model groups, several significant differences were found that are consistent with previous experimental observations. We discuss the implications of our approach and compare its results also with the popular “rate model” of the basal ganglia. Our study suggests that a model-based analysis of imaging data from healthy and Parkinsonian subjects is a promising approach for the future to better understand Parkinson-related changes in the basal ganglia and corresponding treatments.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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