Journal Article

FZJ-2020-05159

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Toward in silico CMC: An industrial collaborative approach to model‐based process development

Roush, D. (Corresponding author) ; Asthagiri, D. ; Babi, D. K. ; Benner, S. ; Bilodeau, C. ; Carta, G. ; Ernst, P.FZJ* ; Fedesco, M. ; Fitzgibbon, S. ; Flamm, M. ; Griesbach, J. ; Grosskopf, T. ; Hansen, E. B. ; Hahn, T. ; Hunt, S. ; Insaidoo, F. ; Lenhoff, A. ; Lin, J. ; Marke, H. ; Marques, B. ; Papadakis, E. ; Schlegel, F. ; Staby, A. ; Stenvang, M. ; Sun, L. ; Tessier, P. M. ; Todd, R. ; Lieres, E.FZJ* ; Welsh, J. ; Willson, R. ; Wang, G. ; Wucherpfennig, T. ; Zavalov, O.

2020
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/27001  doi:10.1002/bit.27520

Abstract: The Third Modeling Workshop focusing on bioprocess modeling was held in Kenilworth, NJ in May 2019. A summary of these Workshop proceedings is captured in this manuscript. Modeling is an active area of research within the biotechnology community, and there is a critical need to assess the current state and opportunities for continued investment to realize the full potential of models, including resource and time savings. Beyond individual presentations and topics of novel interest, a substantial portion of the Workshop was devoted toward group discussions of current states and future directions in modeling fields. All scales of modeling, from biophysical models at the molecular level and up through large scale facility and plant modeling, were considered in these discussions and are summarized in the manuscript. Model life cycle management from model development to implementation and sustainment are also considered for different stages of clinical development and commercial production. The manuscript provides a comprehensive overview of bioprocess modeling while suggesting an ideal future state with standardized approaches aligned across the industry.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 583 - Innovative Synergisms (POF3-583) (POF3-583)

Appears in the scientific report 2020

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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