Journal Article

FZJ-2020-05205

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png On the stationary frequency of programmed ribosomal −1 frameshift

Schütz, G. M. (Corresponding author)FZJ*

2020
IOP Publ. Bristol

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Please use a persistent id in citations: doi:10.1088/1742-5468/ab7a1d

Abstract: We present a stochastic model for programmed ribosomal −1 frameshift, triggered by a slippery sequence and a following pseudoknot on the mRNA template, that allows for the exact derivation of the stationary distribution of ribosome positions and for exact analytical calculations of the stationary rate of frameshift, its efficiency and other quantities of interest. We also present the stationary phase diagram as a function of the initiation rate and the density ribosomes that the pseudoknot can support. These observations provide mathematically rigorous evidence for the notion that the density of molecular motors is an important control parameter for the elongation rate in the presence of slippery sequences both in transcription of RNA and translation of proteins.

Note: Kein Post-print vorhanden!

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Contributing Institute(s):

1. Theoretische Physik der Lebenden Materie (IBI-5)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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