Journal Article

FZJ-2021-02033

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice

Bärmann, J. ; Walter, H. L. ; Pikhovych, A. ; Endepols, H.FZJ* ; Fink, G. R.FZJ* ; Rueger, M. A. ; Schroeter, M. (Corresponding author)

2021
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/27735  doi:10.1016/j.neulet.2021.135811

Abstract: The purpose of this study was to evaluate CatWalk’s capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits (neuroscore).The neuroscore demonstrated deficits of the contralateral forelimb for more than two weeks after stroke. There were no asymmetric or coordinative dysfunctions of limbs detected by CatWalk. However, CatWalk data revealed impairment of locomotion speed and its depending parameters for one-week after stroke in strong correlation to the neuroscore.Data suggest that the composite neuroscore allows to more sensitively and precisely specify and quantify photothrombosis-induced hemisyndromes than CatWalk.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Nuklearchemie (INM-5)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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