Journal Article

FZJ-2021-02936

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families

Guzman-Parra, J. ; Streit, F. ; Forstner, A. J.FZJ* ; Strohmaier, J. ; González, M. J. ; Gil Flores, S. ; Cabaleiro Fabeiro, F. J. ; del Río Noriega, F. ; Perez Perez, F. ; Haro González, J. ; Orozco Diaz, G. ; de Diego-Otero, Y. ; Moreno-Kustner, B. ; Auburger, G. ; Degenhardt, F. ; Heilmann-Heimbach, S. ; Herms, S. ; Hoffmann, P. ; Frank, J. ; Foo, J. C. ; Sirignano, L. ; Witt, S. H. ; Cichon, S.FZJ* ; Rivas, F. ; Mayoral, F. ; Nöthen, M. M. ; Andlauer, T. F. M. (Corresponding author) ; Rietschel, M.

2021
Nature Publishing Group London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/28104  doi:10.1038/s41398-020-01146-0

Abstract: The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less severe form of BD-I. Recent research has challenged this concept of a severity continuum. Studies in large samples of unrelated patients have described clinical and genetic differences between the subtypes. Besides an increased schizophrenia polygenic risk load in BD-I, these studies also observed an increased depression risk load in BD-II patients. The present study assessed whether such clinical and genetic differences are also found in BD patients from multiplex families, which exhibit reduced genetic and environmental heterogeneity. Comparing 252 BD-I and 75 BD-II patients from the Andalusian Bipolar Family (ABiF) study, the clinical course, symptoms during depressive and manic episodes, and psychiatric comorbidities were analyzed. Furthermore, polygenic risk scores (PRS) for BD, schizophrenia, and depression were assessed. BD-I patients not only suffered from more severe symptoms during manic episodes but also more frequently showed incapacity during depressive episodes. A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line with a severity continuum from BD-II to BD-I, our results link BD-I to a more pronounced clinical presentation in both mania and depression and indicate that the polygenic risk load of BD predisposes to more severe disorder characteristics. Nevertheless, our results suggest that the genetic risk burden for depression also shapes disorder presentation and increases the likelihood of BD-II subtype development.

---

Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2021

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---