Journal Article

FZJ-2021-05259

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases

Bogorodskiy, A. ; Okhrimenko, I. ; Burkatovskii, D. ; Jakobs, P. ; Maslov, I. ; Gordeliy, V.FZJ* ; Dencher, N. A. ; Gensch, T.FZJ* ; Voos, W. ; Altschmied, J. ; Haendeler, J. ; Borshchevskiy, V. (Corresponding author)

2021
MDPI Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/29468  doi:10.3390/cells10123528

Abstract: Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.

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Contributing Institute(s):

1. Molekular- und Zellphysiologie (IBI-1)

Research Program(s):

1. 5243 - Information Processing in Distributed Systems (POF4-524) (POF4-524)

Appears in the scientific report 2021

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