Simulating and analyzing the structural plasticity of the brain using HPC

Diaz, Sandra

Talk (non-conference) (Other)

FZJ-2022-00341

Simulating and analyzing the structural plasticity of the brain using HPC

Diaz, S. (Corresponding author)FZJ*

2021

JSC-Jahresabschlusskolloquium 2021, Germany, 16 Dec 2021

Please use a persistent id in citations: http://hdl.handle.net/2128/30052

Abstract: In many fields of science, models are based on sets of differential equations which need to be fit against experimental data. In order to do this, parameter spaces are searched to find specific values which make these models useful to answer relevant scientific questions. In computational neuroscience, models of spiking networks of neurons play an important role in understanding how the brain encodes information and achieves high level cognitive functions. These models are not only of interest for neuroscience but also to many other related fields including artificial intelligence, robotics and control. However, these models are very underconstrained, degenerate and show chaotic dynamics which makes it challenging to find suitable and robust solutions.In this presentation I propose structural plasticity as an optimization algorithm inspired by neurobiology able to generate, modify and tune connectivity parameters for neural network models. Structural plasticity refers to the ability of neurons to change their structure by creating and deleting connections with other neurons in a network in order to preserve specific metabolic levels. First, I introduce the characteristics of structural plasticity as an optimization algorithm together with details about its implementation in NEST, a well-known neural network simulator within the computational neuroscience community. This implementation can efficiently leverage computational resources and is applicable to large scale neural networks. I also briefly present a tool which I have co-developed in order to visualize, analyze and interact with simulations using structural plasticity.The rules under which structural plasticity operates in the brain have been tuned through centuries of natural evolutionary optimization. In the second part of my talk I present how meta-optimization can be used to artificially explore the general rules which make structural plasticity able to work with a variety of network configurations and reach different functional regimes at each portion of the network.

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