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| Hauptseite > Publikationsdatenbank > Hippocampal metabolic subregions and networks: behavioral, molecular and pathological aging profiles |
| Hauptseite > Publikationsdatenbank > Hippocampal metabolic subregions and networks: behavioral, molecular and pathological aging profiles |
| Abstract | FZJ-2022-00588 |
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2021
Abstract: Hippocampal dysfunction happens across many neuropsychiatric disorders and is the hallmark of Alzheimer’s disease (AD) with evidenced metabolic alterations. Based on hippocampal-brain metabolic covariance in a healthy elderly cohort, we found a differentiation into primarily anterior vs. posterior and secondarily CA vs. subiculum subregions. Characterizing the associated metabolic networks revealed that the anterior-subiculum network including temporal-pole and orbitofrontal regions relates to self, motivation and mentalizing behavior and is influenced by dopaminergic systems. In contrast, the posterior-subiculum shows a wide cortical network engaged in action- and world-oriented cognition targeted by serotoninergic systems. The anterior- and posterior-CA, connected respectively to amygdala and broader subcortical networks, are associated to several transporters release. Local metabolism comparison between AD-related diagnosis groups revealed early CA’s alterations while posterior subicular alterations appear at advanced stages in line with broader cortical atrophy and behavioral dysfunctions. Future studies should delineate patients’ individual profiles according to hippocampal subregions and networks.
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