Conference Presentation (Plenary/Keynote)

FZJ-2022-01512

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multi-scale modeling of resting-state activity in human and non-human primate cortices

van Albada, S. (Corresponding author)FZJ*

2022

Abstract: To date, models of the cerebral cortex have seldom combined accounts of the dynamics in local cortical circuits with large-scale activity patterns across multiple areas. I will present supercomputational simulation studies of resting-state activity in macaque and human cerebral cortices which bring together microscopic and macroscopic descriptions of the structure and dynamics. The simulations reproduce key aspects of spiking statistics as well as patterns of fMRI functional connectivity, and support the notion that cerebral cortex is poised just below a state transition. The models can serve as platforms for testing theories of cortical function in a setting constrained by anatomical and physiological data at multiple scales.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. 5235 - Digitization of Neuroscience and User-Community Building (POF4-523) (POF4-523)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. Brain-Scale Simulations (jinb33_20191101) (jinb33_20191101)
5. Brain-Scale Simulations (jinb33_20121101) (jinb33_20121101)
6. SPP 2041 347572269 - Integration von Multiskalen-Konnektivität und Gehirnarchitektur in einem supercomputergestützten Modell der menschlichen Großhirnrinde (347572269) (347572269)
7. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
8. Brain-Scale Simulations (jinb33_20220812) (jinb33_20220812)

Appears in the scientific report 2022

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