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@ARTICLE{Braeutigam:907433,
      author       = {Braeutigam, Andrea and Simsek, Ahmet Nihat and Gompper,
                      Gerhard and Sabass, Benedikt},
      title        = {{G}eneric self-stabilization mechanism for biomolecular
                      adhesions under load},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2022-02033},
      pages        = {2197},
      year         = {2022},
      abstract     = {Mechanical loading generally weakens adhesive structures
                      and eventually leads to their rupture. However, biological
                      systems can adapt to loads by strengthening adhesions, which
                      is essential for maintaining the integrity of tissue and
                      whole organisms. Inspired by cellular focal adhesions, we
                      suggest here a generic, molecular mechanism that allows
                      adhesion systems to harness applied loads for
                      self-stabilization through adhesion growth. The mechanism is
                      based on conformation changes of adhesion molecules that are
                      dynamically exchanged with a reservoir. Tangential loading
                      drives the occupation of some states out of equilibrium,
                      which, for thermodynamic reasons, leads to association of
                      further molecules with the cluster. Self-stabilization
                      robustly increases adhesion lifetimes in broad parameter
                      ranges. Unlike for catch-bonds, bond rupture rates can
                      increase monotonically with force. The self-stabilization
                      principle can be realized in many ways in complex
                      adhesion-state networks; we show how it naturally occurs in
                      cellular adhesions involving the adaptor proteins talin and
                      vinculin.},
      cin          = {IBI-5 / IAS-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IBI-5-20200312 / I:(DE-Juel1)IAS-2-20090406},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35459276},
      UT           = {WOS:000785774400011},
      doi          = {10.1038/s41467-022-29823-2},
      url          = {https://juser.fz-juelich.de/record/907433},
}