Journal Article

FZJ-2022-02033

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Generic self-stabilization mechanism for biomolecular adhesions under load

Braeutigam, A.FZJ* ; Simsek, A. N.FZJ* ; Gompper, G.FZJ* ; Sabass, B. (Corresponding author)FZJ*

2022
Nature Publishing Group UK [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/31088  doi:10.1038/s41467-022-29823-2

Abstract: Mechanical loading generally weakens adhesive structures and eventually leads to their rupture. However, biological systems can adapt to loads by strengthening adhesions, which is essential for maintaining the integrity of tissue and whole organisms. Inspired by cellular focal adhesions, we suggest here a generic, molecular mechanism that allows adhesion systems to harness applied loads for self-stabilization through adhesion growth. The mechanism is based on conformation changes of adhesion molecules that are dynamically exchanged with a reservoir. Tangential loading drives the occupation of some states out of equilibrium, which, for thermodynamic reasons, leads to association of further molecules with the cluster. Self-stabilization robustly increases adhesion lifetimes in broad parameter ranges. Unlike for catch-bonds, bond rupture rates can increase monotonically with force. The self-stabilization principle can be realized in many ways in complex adhesion-state networks; we show how it naturally occurs in cellular adhesions involving the adaptor proteins talin and vinculin.

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Contributing Institute(s):

1. Theoretische Physik der Lebenden Materie (IBI-5)
2. Theorie der Weichen Materie und Biophysik (IAS-2)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2022

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