Novel biocompatible Cu2+-containing composite hydrogels based on bacterial cellulose and poly-1-vinyl-1,2,4-triazole

Smyslov, Ruslan Yu.; Khripunov, Albert K.; Gorshkova, Yulia E.; Kopitsa, Gennady P.; Korzhova, Svetlana A.; Tsvigun, Natalia V.; Ezdakova, Ksenia V.; Pozdnyakov, Alexander S.; Emel'yanov, Artem I.; Migunova, Alexandra V.

doi:10.1016/j.smaim.2022.05.002

Journal Article

FZJ-2022-02685

Novel biocompatible Cu2+-containing composite hydrogels based on bacterial cellulose and poly-1-vinyl-1,2,4-triazole

Smyslov, R. Y. (Corresponding author) ; Kopitsa, G. P. ; Gorshkova, Y. E. ; Ezdakova, K. V. ; Khripunov, A. K. ; Migunova, A. V. ; Tsvigun, N. V. ; Korzhova, S. A. ; Emel'yanov, A. I. ; Pozdnyakov, A. S.

2022
Elsevier Amsterdam

Smart materials in medicine 3, 382 - 389 (2022) [10.1016/j.smaim.2022.05.002]

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Please use a persistent id in citations: http://hdl.handle.net/2128/31465 doi:10.1016/j.smaim.2022.05.002

Abstract: Novel composite hydrogels representing interpenetrating polymeric networks (IPN) have been synthesized and consisted of Gluconacetobacter xylinus cellulose (GxC) and poly-1-vinyl-1,2,4-triazole (PVT) with Cu2⁺. The composite hydrogels’ mesostructure has been studied from 1.6 nm to 2.5 μm by small-angle and ultra-small-angle neutron scattering methods. It has been found that IPN complexes have three types of inhomogeneities: GxC, PVT, and PVT complex with Cu2⁺. The amount of the absorbed ions can be tuned as confirmed by electron paramagnetic spectroscopy. Besides, three hierarchy levels of GxC remained in the supramolecular structure of composite hydrogels. Reveling structure formation in these composite hydrogels is essential in fabricating hybrid polymeric materials for regenerative medicine, involving antibacterial or antifungal applications.

Keyword(s): Health and Life (1st) ; Medicine (2nd) ; Chemistry (2nd) ; Industrial Application (2nd)

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