Journal Article

FZJ-2022-03545

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The role of chemistry in accelerator-based production and separation of radionuclides as basis for radiolabelled compounds for medical applications

Qaim, S. M.FZJ* ; Spahn, I. (Corresponding author)FZJ* ; Scholten, B. ; Spellerberg, S.FZJ* ; Neumaier, B.FZJ*

2022
˜Deœ Gruyter Berlin

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Please use a persistent id in citations: doi:10.1515/ract-2022-0017

Abstract: Radiochemical separations used in large scale routine production of diagnostic and therapeutic radionuclides at a particle accelerator for patient care are briefly outlined. The role of chemistry at various stages of development of a production route of a novel radionuclide, namely nuclear data measurement, high-current targetry, chemical processing and quality control of the product, is discussed in detail. Special attention is paid to production of non-standard positron emitters (e.g. 44gSc, 64Cu, 68Ga, etc.) at a cyclotron and novel therapeutic radionuclides (e.g. 67Cu, 225Ac, etc.) at an accelerator. Some typical examples of radiochemical methods involved are presented.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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