Journal Article

FZJ-2022-04078

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biomarkers Derived from Alterations in Overlapping Community Structure of Resting-state Brain Functional Networks for Detecting Alzheimer’s Disease

Han, H. ; Li, X.FZJ* ; Gan, J. Q. ; Yu, H. ; Wang, H. (Corresponding author)

2022
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/32364  doi:10.1016/j.neuroscience.2021.12.031

Abstract: Recent studies show that overlapping community structure is an important feature of the brain functional network. However, alterations in such overlapping community structure in Alzheimer’s disease (AD) patients have not been examined yet. In this study, we investigate the overlapping community structure in AD by using resting-state functional magnetic resonance imaging (rs-fMRI) data. The collective sparse symmetric non-negative matrix factorization (cssNMF) is adopted to detect the overlapping community structure. Experimental results on 28 AD patients and 32 normal controls (NCs) from the ADNI2 dataset show that the two groups have remarkable differences in terms of the optimal number of communities, the hierarchy of communities detected at different scales, network functional segregation, and nodal functional diversity. In particular, the frontal-parietal and basal ganglia networks exhibit significant differences between the two groups. A machine learning framework proposed in this paper for AD detection achieved an accuracy of 76.7% when using the detected community strengths of the frontal-parietal and basal ganglia networks only as input features. These findings provide novel insights into the understanding of pathological changes in the brain functional network organization of AD and show the potential of the community structure-related features for AD detection.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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