Journal Article

FZJ-2022-05720

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Imaging patterns in patients with newly diagnosed glioblastoma in England

Galldiks, N. (Corresponding author)FZJ* ; Lohmann, P.FZJ*

2022
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/33903  doi:10.1093/nop/npac059

Abstract: The study by Dumba and colleagues1 explored the incidence and timing of various peridiagnostic neuroimaging techniques such as MRI, CT, and PET in patients with newly diagnosed glioblastoma using a national database. Particularly, preoperative, early postoperative, and pre-radiotherapy imaging patterns for all glioblastoma patients aged 15–99 years resident in England in the years 2013 and 2014 were retrospectively evaluated.The entire cohort for data analysis comprised 4,307 patients. The main finding of the study is that prediagnostic imaging appears uniform, whereas postdiagnostic imaging practice varied considerably. Of note, the authors observed that there is clear evidence for low use of early postoperative MRI, the low use of additional MR imaging before radiotherapy, and the very limited use of other neuroimaging techniques such as advanced MRI and PET. For example, in the group of patients who underwent surgery and chemoradiation, only 51% had an early postoperative MRI within 72 hours after surgery. In patients undergoing surgery who subsequently received radiotherapy, only 61% had both an early postoperative and a pre-radiotherapy MRI. To improve the diagnostic performance, only 7% of the cohort underwent one or more of the advanced MRI options (ie, perfusion-weighted MRI, proton MR spectroscopy), and less than 1% of the cohort had additional PET imaging with various tracers (eg, radiolabeled amino acids, [18F]-2-fluoro-2-deoxy-D-glucose) during the course of the disease.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Emerging Sources Citation Index ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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