Journal Article

FZJ-2023-00918

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ferritin self-assembly, structure, function, and biotechnological applications

Sudarev, V. V. ; Dolotova, S. M. ; Bukhalovich, S. M. ; Bazhenov, S. V. ; Ryzhykau, Y. L. ; Uversky, V. N. ; Bondarev, N. A. ; Osipov, S. D. ; Mikhailov, A. E. ; Kuklina, D. D. ; Murugova, T. N. ; Manukhov, I. V. ; Rogachev, A. V. ; Gordeliy, V. I.FZJ* ; Gushchin, I. Y. ; Kuklin, A. I. ; Vlasov, A. V. (Corresponding author)

2023
Elsevier New York, NY [u.a.]

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/33831  doi:10.1016/j.ijbiomac.2022.10.126

Abstract: Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It plays a crucial role in various metabolic pathways, inflammation processes, stress response, and pathogenesis of cancer and neurodegenerative diseases. In this review we discuss the role of ferritin in diseases, cellular iron regulation, its structural features, and its role in biotechnology. We also show that molecular mechanisms of ferritin self-assembly are key for a number of biotechnological and pharmaceutical applications. The assembly pathways strongly depend on the interface context of ferritin monomers and the stability of its different intermediate oligomers. To date, several schemes of self-assembly kinetics have been proposed. Here, we compare different self-assembly mechanisms and discuss the possibility of self-assembly control by switching between deadlock intermediate states.

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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