%0 Journal Article
%A Midya, Jiarul
%A Auth, Thorsten
%A Gompper, Gerhard
%T Membrane-Mediated Interactions Between Nonspherical Elastic Particles
%J ACS nano
%V 17
%N 3
%@ 1936-0851
%C Washington, DC
%I Soc.
%M FZJ-2023-01081
%P 1935–1945
%D 2023
%X The transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with their environment. Large particles often get wrapped by membranes, a process which has been intensively investigated in the case of hard particles. However, many particles in vivo and in vitro are deformable, e.g., vesicles, filamentous viruses, macromolecular condensates, polymer-grafted nanoparticles, and microgels. Vesicles may serve as a generic model system for deformable particles. Here, we study nonspherical vesicles with various sizes, shapes, and elastic properties at initially planar lipid-bilayer membranes. Using the Helfrich Hamiltonian, triangulated membranes, and energy minimization, we predict the interplay of vesicle shapes and wrapping states. Increasing particle softness enhances the stability of shallow-wrapped and deep-wrapped states over nonwrapped and complete-wrapped states. The free membrane mediates an interaction between partial-wrapped vesicles. For the pair interaction between deep-wrapped vesicles, we predict repulsion. For shallow-wrapped vesicles, we predict attraction for tip-to-tip orientation and repulsion for side-by-side orientation. Our predictions may guide the design and fabrication of deformable particles for efficient use in medical applications, such as targeted drug delivery.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36669092
%U <Go to ISI:>//WOS:000921840800001
%R 10.1021/acsnano.2c05801
%U https://juser.fz-juelich.de/record/972119