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@ARTICLE{Midya:972119,
author = {Midya, Jiarul and Auth, Thorsten and Gompper, Gerhard},
title = {{M}embrane-{M}ediated {I}nteractions {B}etween
{N}onspherical {E}lastic {P}articles},
journal = {ACS nano},
volume = {17},
number = {3},
issn = {1936-0851},
address = {Washington, DC},
publisher = {Soc.},
reportid = {FZJ-2023-01081},
pages = {1935–1945},
year = {2023},
abstract = {The transport of particles across lipid-bilayer membranes
is important for biological cells to exchange information
and material with their environment. Large particles often
get wrapped by membranes, a process which has been
intensively investigated in the case of hard particles.
However, many particles in vivo and in vitro are deformable,
e.g., vesicles, filamentous viruses, macromolecular
condensates, polymer-grafted nanoparticles, and microgels.
Vesicles may serve as a generic model system for deformable
particles. Here, we study nonspherical vesicles with various
sizes, shapes, and elastic properties at initially planar
lipid-bilayer membranes. Using the Helfrich Hamiltonian,
triangulated membranes, and energy minimization, we predict
the interplay of vesicle shapes and wrapping states.
Increasing particle softness enhances the stability of
shallow-wrapped and deep-wrapped states over nonwrapped and
complete-wrapped states. The free membrane mediates an
interaction between partial-wrapped vesicles. For the pair
interaction between deep-wrapped vesicles, we predict
repulsion. For shallow-wrapped vesicles, we predict
attraction for tip-to-tip orientation and repulsion for
side-by-side orientation. Our predictions may guide the
design and fabrication of deformable particles for efficient
use in medical applications, such as targeted drug
delivery.},
cin = {IBI-5 / IAS-2},
ddc = {540},
cid = {I:(DE-Juel1)IBI-5-20200312 / I:(DE-Juel1)IAS-2-20090406},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
pubmed = {36669092},
UT = {WOS:000921840800001},
doi = {10.1021/acsnano.2c05801},
url = {https://juser.fz-juelich.de/record/972119},
}