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| Hauptseite > Publikationsdatenbank > Subclinical motor involvement in nonsystemic vasculitic neuropathy determined by the motor unit number estimation method MScanFit |
| Hauptseite > Publikationsdatenbank > Subclinical motor involvement in nonsystemic vasculitic neuropathy determined by the motor unit number estimation method MScanFit |
| Journal Article | FZJ-2023-01617 |
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2023
Wiley
New York, NY [u.a.]
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Please use a persistent id in citations: doi:10.1002/mus.27813 doi:10.34734/FZJ-2023-01617
Abstract: Abstract: Introduction/Aims:Nonsystemic vasculitic neuropathy(NSVN) is characterized by a pre-dominant lower limb involvement in many patients. Motor unit changes in upper extremitymuscles have not been investigated in this subgroup but may be of interest for improvingour understanding of the multifocal nature of the disease and counseling of patients aboutpotential future symptoms. In this study we aimed to better understand subclinical motorinvolvement in the upper extremity muscles of patients with lower limb–predominantNSVN using the new motor unit number estimation (MUNE) method MScanFit.Methods:In this single-center, cross-sectionalstudy, 14 patients with biopsy-provenNSVN, with no clinical signs of upper extremity motor involvement, were investigatedand compared with 14 age-matched healthy controls. All participants were assessed clini-cally and by the MUNE method MScanFit tothe abductor pollicis brevis muscle.Results:The number of motor units and peak CMAP amplitudes were significantlyreduced in patients with NSVN (P=.003 andP=.004, respectively). Absolutemedian motor unit amplitudes and CMAP discontinuities were not significantly dif-ferent (P=.246 andP=.1, respectively). CMAP discontinuities were not signifi-cantly correlated with motor unit loss (P=.15, rho=0.4). The number of motorunits did not correlate with clinical scores (P=.77, rho=0.082).Discussion:Both MUNE and CMAP amplitudes showed motor involvement in upperextremity muscles in lower limb–predominant NSVN. Overall, there was no evidenceof significant reinnervation. Investigations of the abductor pollicis brevis muscle didnot show a correlation with overall functional disability of the patients.KEYWORDSmotor unit number estimation, MScanFit, polyneuropathy, vasculitic neuropathy, vasculitis
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