Contribution to a conference proceedings/Journal Article

FZJ-2023-01623

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Passive mixer model for multi-contrast magnetic particle spectroscopy

Bikulov, T. (Corresponding author)FZJ* ; Offenhäusser, A.FZJ* ; Krause, H.-J.FZJ*

2023
Infinite Science Publishing Lübeck

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Please use a persistent id in citations: http://hdl.handle.net/2128/34228  doi:10.18416/ijmpi.2023.2303087  doi:10.18416/IJMPI.2023.2303087

Abstract: For realizing multi-contrast MPI with different types of SuperParamagnetic Nanoparticles (SPN), reconstruction of the particles’ core diameter distribution is required for various points in space. We propose a principle for distinguishing signals from SPNs of different diameters, which exploits the offset field concept already used in MPI. We show that precise reconstruction of Magnetization Curve (MC) is the key to precise reconstruction of core diameter distribution, as all information about distribution is stored in the curvature. A Passive Mixer Model is proposed in order to uniquely relate the MC to the intermodulation products in the magnetization spectra. The model does not require small signal assumption and hence does not lose accuracy in the reconstruction under large excitation fields. We show that a number of useful practical conclusions can be drawn from this model.

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2023

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Database coverage:
; ; ; SCOPUS

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