Journal Article

FZJ-2023-02378

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease

Strelow, J. N. (Corresponding author) ; Dembek, T. A. ; Baldermann, J. C. ; Andrade, P. ; Fink, G. R.FZJ* ; Visser-Vandewalle, V. ; Barbe, M. T.

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.parkreldis.2023.105478  doi:10.34734/FZJ-2023-02378

Abstract: AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2023

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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