Journal Article

FZJ-2024-02639

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png MRI- or 18F-FDG PET-derived brain age gaps: Associations with markers of Alzheimer's disease

Doering, E. ; Antonopoulos, G.FZJ* ; Hönig, M.FZJ* ; van Eimeren, T. ; Daamen, M. ; Boecker, H. ; Jessen, F. ; Duezel, E. ; Eickhoff, S.FZJ* ; Patil, K.FZJ* ; Drzezga, A.FZJ*

2024
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.clinph.2023.12.043

Abstract: When the age of an individual's brain appears older than their chronological age, i.e., when the brain age gap (BAG) is positive, it may indicate the presence of a neurodegenerative condition, such as Alzheimer’s disease (AD). In this study, we evaluated whether BAG, determined by MRI (reflecting atrophy) or 18F-FDG PET (reflecting brain metabolism), correlate differentially with cognitive function, neuropathological indicators, and disease progression in individuals with normal cognitive function (CN), as well as those with subjective cognitive decline (SCD) or mild cognitive impairment (MCI).

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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