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| Typ | Amount | VAT | Currency | Share | Status | Cost centre |
| APC | 2523.00 | 0.00 | EUR | 100.00 % | (Zahlung erfolgt) | ZB |
| Sum | 2523.00 | 0.00 | EUR | |||
| Total | 2523.00 |
| Journal Article | FZJ-2024-03333 |
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2024
Molecular Diversity Preservation International
Basel
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Please use a persistent id in citations: doi:10.3390/ijms25094966 doi:10.34734/FZJ-2024-03333
Abstract: Herpes simplex virus (HSV) infections are highly widespread among humans, producing symptoms ranging from ulcerative lesions to severe diseases such as blindness and life-threatening encephalitis. At present, there are no vaccines available, and some existing antiviral treatments can be ineffective or lead to adverse effects. As a result, there is a need for new anti-HSV drugs. In this report, the in vitro anti-HSV effect of 9,9'-norharmane dimer (nHo-dimer), which belongs to the β-carboline (βC) alkaloid family, was evaluated. The dimer exhibited no virucidal properties and did not impede either the attachment or penetration steps of viral particles. The antiviral effect was only exerted under the constant presence of the dimer in the incubation media, and the mechanism of action was found to involve later events of virus infection. Analysis of fluorescence lifetime imaging data showed that the nHo-dimer internalized well into the cells when present in the extracellular incubation medium, with a preferential accumulation into perinuclear organelles including mitochondria. After washing the host cells with fresh medium free of nHo-dimer, the signal decreased, suggesting the partial release of the compound from the cells. This agrees with the observation that the antiviral effect is solely manifested when the alkaloid is consistently present in the incubation media.
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